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Adversarial pharmacovigilance on public data
Pre-registered. Multi-trial. Cryptographically attested. Reproducible.

Caliper validates biomedical claims by running them through an adversarial pipeline that pre-registers the methodology, queries public-data evidence, aggregates multi-trial LLM verdicts with documented dissent, and publishes cryptographically-locked audit chains. The platform exists to catch overclaims — including its own — before they reach the public.

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Published findings
224 adversarial findings on disk · all sha1-locked

Anti-Amyloid Antibodies (Leqembi, Kisunla) — Post-Market AE Divergence

Caliper's FAERS pharmacovigilance analysis identifies 21 off-label AE signals across lecanemab + donanemab. Donanemab shows materially higher hypersensitivity rates than lecanemab in head-to-head FAERS.
Audit-grade
sha1: b31f188d89d161be…

Canagliflozin Amputation Signal Persisted After FDA Removed Boxed Warning

FDA removed the canagliflozin amputation boxed warning August 2020. FAERS post-removal data shows the disproportionality signal persists at PRR = 4.25 vs other SGLT2 inhibitors.
Audit-grade
sha1: 20cad3aa91ea6c78…

Top 10 Worst-Emergent-Signal Drugs of FDA Novel Approvals 2020-2024

Systematic FAERS scan across 55 curated 2020-2024 FDA novel approvals. Ranked by count of off-label adverse-event signals meeting Evans criteria.
Audit-grade ranking
sha1: a7479b7b1a5f68f2…

Isatuximab → Infusion related reaction — Null result

Caliper validation of the submitted claim (drug=isatuximab, AE=Infusion related reaction). COEXPOSURE_CONFOUNDED — ? at 0% co-exposure; signal not attributable to isatuximab alone
Did not validate
sha1: 3489aa05d95482e5…

Tirzepatide → Pancreatitis — Null result

Caliper validation of the submitted claim (drug=tirzepatide, AE=Pancreatitis). COEXPOSURE_CONFOUNDED — ? at 0% co-exposure; signal not attributable to tirzepatide alone
Did not validate
sha1: 9da24e5ee0c4d565…

Tirzepatide → Earache — Null result

Caliper validation of the submitted claim (drug=tirzepatide, AE=Earache). BELOW_DEDUP_THRESHOLD — candidate did not validate at dedup
Did not validate
sha1: ec501530b0b62737…

Mavacamten → Heart failure — Null result

Caliper validation of the submitted claim (drug=mavacamten, AE=Heart failure). BELOW_DEDUP_THRESHOLD — candidate did not validate at dedup
Did not validate
sha1: be60dc12e23d5a07…

Tirzepatide → Acute kidney injury — Null result

Caliper validation of the submitted claim (drug=tirzepatide, AE=Acute kidney injury). BELOW_PRR_THRESHOLD — disproportionality not significant (PRR=0.34, lower CI=0.27)
Did not validate
sha1: d3cb673fca101e4a…

Fezolinetant → Hepatotoxicity — Audit-grade candidate

Caliper validation of the submitted claim (drug=fezolinetant, AE=Hepatotoxicity). PRR = 3.86 (95% CI 1.93–7.71), n = 8 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 871ee0d5a9a516b2…

Tezepelumab → Headache — Null result

Caliper validation of the submitted claim (drug=tezepelumab, AE=Headache). BELOW_PRR_THRESHOLD — disproportionality not significant (PRR=1.27, lower CI=1.12)
Did not validate
sha1: 060e0cb6a21f5650…

Inclisiran → Injection site reaction — Audit-grade candidate

Caliper validation of the submitted claim (drug=inclisiran, AE=Injection site reaction). PRR = 8.10 (95% CI 7.07–9.29), n = 201 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: c816fe79e82f765c…

Remdesivir → Acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=remdesivir, AE=Acute kidney injury). PRR = 6.45 (95% CI 5.97–6.96), n = 624 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: a91f60dff2779fd3…

Ozanimod → Bradycardia — Null result

Caliper validation of the submitted claim (drug=ozanimod, AE=Bradycardia). BELOW_PRR_THRESHOLD — disproportionality not significant (PRR=0.83, lower CI=0.54)
Did not validate
sha1: 505f7700db29c8bf…

Tirzepatide → Cholelithiasis — Null result

Caliper validation of the submitted claim (drug=tirzepatide, AE=Cholelithiasis). BELOW_PRR_THRESHOLD — disproportionality not significant (PRR=1.37, lower CI=1.06)
Did not validate
sha1: 66e748485ac7483c…

Fezolinetant → Hepatic enzyme increased — Audit-grade candidate

Caliper validation of the submitted claim (drug=fezolinetant, AE=Hepatic enzyme increased). PRR = 27.01 (95% CI 23.41–31.15), n = 172 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: ee63d7b075ba1633…

Fezolinetant → Alanine aminotransferase increased — Audit-grade candidate

Caliper validation of the submitted claim (drug=fezolinetant, AE=Alanine aminotransferase increased). PRR = 31.71 (95% CI 27.62–36.41), n = 183 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 3d31390518094389…

Tirzepatide → Nausea — Audit-grade candidate

Caliper validation of the submitted claim (drug=tirzepatide, AE=Nausea). PRR = 3.15 (95% CI 3.05–3.26), n = 3124 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 7ff01f7d9aee9608…

Adagrasib → Hepatotoxicity — Null result

Caliper validation of the submitted claim (drug=adagrasib, AE=Hepatotoxicity). BELOW_DEDUP_THRESHOLD — only 4 unique cases after dedup; insufficient signal density
Did not validate
sha1: 984d096614c22171…

Ozanimod → Macular oedema — Audit-grade candidate

Caliper validation of the submitted claim (drug=ozanimod, AE=Macular oedema). PRR = 9.70 (95% CI 6.70–14.05), n = 28 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: f61184498d025845…

Tirzepatide → Vomiting — Audit-grade candidate

Caliper validation of the submitted claim (drug=tirzepatide, AE=Vomiting). PRR = 2.00 (95% CI 1.90–2.12), n = 1194 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: f8e23bca31f091a0…

Tirzepatide → Diarrhoea — Null result

Caliper validation of the submitted claim (drug=tirzepatide, AE=Diarrhoea). BELOW_PRR_THRESHOLD — disproportionality not significant (PRR=1.70, lower CI=1.61)
Did not validate
sha1: 51d40b4fa8a85a99…

Tirzepatide → Diarrhoea — Null result

Caliper validation of the submitted claim (drug=tirzepatide, AE=Diarrhoea). BELOW_PRR_THRESHOLD — disproportionality not significant (PRR=1.70, lower CI=1.61)
Did not validate
sha1: a529d27894a60508…

Fezolinetant → Liver function test increased — Audit-grade candidate (scan)

Discovered via single-drug scan of fezolinetant. PRR = 42.41 (95% CI 34.39–52.30), n = 84 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: e32b2fcd3e6651a0…

Fezolinetant → Alanine aminotransferase increased — Audit-grade candidate (scan)

Discovered via single-drug scan of fezolinetant. PRR = 31.71 (95% CI 27.62–36.41), n = 183 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 7784f20db65a1bb7…

Fezolinetant → Aspartate aminotransferase increased — Audit-grade candidate (scan)

Discovered via single-drug scan of fezolinetant. PRR = 28.04 (95% CI 23.90–32.90), n = 140 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: ec5a1153247e2dfc…

Fezolinetant → Hepatic enzyme increased — Audit-grade candidate (scan)

Discovered via single-drug scan of fezolinetant. PRR = 27.01 (95% CI 23.41–31.15), n = 172 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: c2c8b3c9b8d736f1…

Fezolinetant → Gamma-glutamyltransferase increased — Audit-grade candidate (scan)

Discovered via single-drug scan of fezolinetant. PRR = 18.65 (95% CI 13.66–25.45), n = 39 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 691ce541272c2df1…

Fezolinetant → Hot flush — Audit-grade candidate (scan)

Discovered via single-drug scan of fezolinetant. PRR = 13.51 (95% CI 11.12–16.43), n = 96 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 52e950e6464aab75…

Fezolinetant → Night sweats — Audit-grade candidate (scan)

Discovered via single-drug scan of fezolinetant. PRR = 11.25 (95% CI 8.06–15.70), n = 34 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: b90bf4bb1550e6be…

Fezolinetant → Insomnia — Audit-grade candidate (scan)

Discovered via single-drug scan of fezolinetant. PRR = 3.10 (95% CI 2.53–3.81), n = 87 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: e172edaf5e51021a…

Fezolinetant → Abdominal pain upper — Audit-grade candidate (scan)

Discovered via single-drug scan of fezolinetant. PRR = 2.29 (95% CI 1.71–3.06), n = 44 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 1856dd1b8799e104…

Tirzepatide → Diarrhoea — Null result

Caliper validation of the submitted claim (drug=tirzepatide, AE=Diarrhoea). BELOW_PRR_THRESHOLD — disproportionality not significant (PRR=1.70, lower CI=1.61)
Did not validate
sha1: c96eced15564039a…

Tirzepatide → Nausea — Audit-grade candidate

Caliper validation of the submitted claim (drug=tirzepatide, AE=Nausea). PRR = 3.15 (95% CI 3.05–3.26), n = 3124 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 5ad9eec52dc8e98a…

Tirzepatide → Diarrhoea — Null result

Caliper validation of the submitted claim (drug=tirzepatide, AE=Diarrhoea). BELOW_PRR_THRESHOLD — disproportionality not significant (PRR=1.70, lower CI=1.61)
Did not validate
sha1: 60c5d63eb6f2f0df…

Tirzepatide → Diarrhoea — Null result

Caliper validation of the submitted claim (drug=tirzepatide, AE=Diarrhoea). BELOW_PRR_THRESHOLD — disproportionality not significant (PRR=1.70, lower CI=1.61)
Did not validate
sha1: 64f6350e8ec21d90…

Clozapine → agranulocytosis — Audit-grade candidate

Caliper validation of the submitted claim (drug=clozapine, AE=agranulocytosis). PRR = 26.69 (95% CI 24.62–28.92), n = 599 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: fd01ba4c4ae5c7a8…

Aspirin → alopecia areata — Null result

Caliper validation of the submitted claim (drug=aspirin, AE=alopecia areata). BELOW_DEDUP_THRESHOLD — only 1 unique cases after dedup; insufficient signal density
Did not validate
sha1: a94bc248d7387910…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 729453ddefa81d4c…

Semaglutide → thyroid cancer — Null result

Caliper validation of the submitted claim (drug=semaglutide, AE=thyroid cancer). BELOW_PRR_THRESHOLD — disproportionality not significant (PRR=1.44, lower CI=1.00)
Did not validate
sha1: b25d8cde3fad9bfe…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: bd00677f4f0d3cd9…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: e4e234b899c6355b…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 237b899564d8524c…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: a8a06658d47be7ce…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 3bada8445d3c31f0…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: a8c13ec3623c4ceb…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 64085bc4a1dc25d1…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 84fe13d4e08ea7d3…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: b860fd936b8f062d…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: fd0bc89ba7675c1f…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 21cc902cedb2c679…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: f83d1fbed1629163…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 9b1a5981161e303e…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 9c84b368f892ad3b…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: b41903e1b3e376cc…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: bcae42e884c4b3a5…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 64a16cfa79037aa4…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 5cd1e19842c39da4…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 6e85762c3419d353…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 177ea1357a0b654d…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: ded4d16a349756fe…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 5930101fad299882…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: a26f6e3500b11633…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: a851d0d9e591a332…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 8e00195e5ad5f6e7…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 15fec8e4d5852f36…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 6142bfbbaab0338e…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 3d6606c37dbfa1e7…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 0553fe93050806ea…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 2df5c8eabcf06f0e…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 8cb0690e8f9fcccc…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 768c1878e66d1119…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: ac3a9653b1736228…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: ee22317a9a945a98…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: ee22317a9a945a98…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: e0a358983cc07178…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 38a14585928ef23a…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: f7c7d0236d7d1538…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 29d5e27d25cd26d8…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 3ffa4e8ca48a3fec…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 3ffa4e8ca48a3fec…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: a45c5573c47ad9b8…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: a14b7385aa1186d2…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 99be0a55c8b2e032…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 2f775d9aa9af423d…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 21d71a56264f9be9…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 157461da2985346c…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 157461da2985346c…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: e0bfc95e13cb5f34…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 0ddd100da2b972dc…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: bfa7ebb9b4c9e9d5…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 83336b0f691cb806…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 83336b0f691cb806…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 1392ba8a0ab22c82…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 8a81e3ca83eef3d6…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 8a81e3ca83eef3d6…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: d3d2c66893ec8ead…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: afbaac8b044458b1…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 0c4b6b1102e40aa6…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 0c4b6b1102e40aa6…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: b297c11c2e06376e…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: aeabc7036d0a731d…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: aeabc7036d0a731d…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 4309c3991e5bb564…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: a6dc9d87971d9d51…

Empagliflozin → acute kidney injury — Audit-grade candidate

Caliper validation of the submitted claim (drug=empagliflozin, AE=acute kidney injury). PRR = 3.05 (95% CI 2.82–3.31), n = 583 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: e9aad61ae9d8b705…

Aspirin → headache — Null result

Caliper validation of the submitted claim (drug=aspirin, AE=headache). BELOW_PRR_THRESHOLD — disproportionality not significant (PRR=0.86, lower CI=0.80)
Did not validate
sha1: 33fb95387128d6d6…

Aspirin → headache — Null result

Caliper validation of the submitted claim (drug=aspirin, AE=headache). BELOW_PRR_THRESHOLD — disproportionality not significant (PRR=0.86, lower CI=0.80)
Did not validate
sha1: 38b0633b1406e350…

Aspirin → script alert 1 script — Null result

Caliper validation of the submitted claim (drug=aspirin, AE=script alert 1 script). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: e1c3c8589f79b1a5…

Aspirin Or 1=1 → headache — Null result

Caliper validation of the submitted claim (drug=aspirin OR 1=1, AE=headache). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: 6f9440af9b499d1a…

Ratetest → ratetest — Null result

Caliper validation of the submitted claim (drug=ratetest, AE=ratetest). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: 0538c90ec16b600d…

Ratetest → ratetest — Null result

Caliper validation of the submitted claim (drug=ratetest, AE=ratetest). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: a2fc5fb1511c70ef…

Ratetest → ratetest — Null result

Caliper validation of the submitted claim (drug=ratetest, AE=ratetest). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: a2fc5fb1511c70ef…

Ratetest → ratetest — Null result

Caliper validation of the submitted claim (drug=ratetest, AE=ratetest). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: bc649d16d4c5522a…

Ratetest → ratetest — Null result

Caliper validation of the submitted claim (drug=ratetest, AE=ratetest). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: 7147137e7439a423…

Ratetest → ratetest — Null result

Caliper validation of the submitted claim (drug=ratetest, AE=ratetest). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: 00535294b1c19f03…

Ratetest → ratetest — Null result

Caliper validation of the submitted claim (drug=ratetest, AE=ratetest). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: c053a403d8f9af59…

Ratetest → ratetest — Null result

Caliper validation of the submitted claim (drug=ratetest, AE=ratetest). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: a35346d6063c66fe…

Ratetest → ratetest — Null result

Caliper validation of the submitted claim (drug=ratetest, AE=ratetest). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: 2e10d1c53bf12fb4…

Ratetest → ratetest — Null result

Caliper validation of the submitted claim (drug=ratetest, AE=ratetest). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: da37c611c3c4d922…

Metformin → lactic acidosis — Audit-grade candidate

Caliper validation of the submitted claim (drug=metformin, AE=lactic acidosis). PRR = 15.61 (95% CI 14.43–16.90), n = 614 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: c15768cc5d12ad02…

Semaglutide → Blood glucose increased — Audit-grade candidate (scan)

Discovered via single-drug scan of semaglutide. PRR = 6.68 (95% CI 6.37–7.01), n = 1589 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: a244dc41ca7a2d0d…

Semaglutide → Decreased appetite — Audit-grade candidate (scan)

Discovered via single-drug scan of semaglutide. PRR = 5.65 (95% CI 5.39–5.92), n = 1637 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: d6cffa71c7cd8c28…

Semaglutide → Weight decreased — Audit-grade candidate (scan)

Discovered via single-drug scan of semaglutide. PRR = 4.70 (95% CI 4.49–4.93), n = 1648 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 93b77ef0ed63b1f9…

Semaglutide → Constipation — Audit-grade candidate (scan)

Discovered via single-drug scan of semaglutide. PRR = 4.56 (95% CI 4.32–4.82), n = 1231 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 1e025a00ff49f109…

Semaglutide → Nausea — Audit-grade candidate (scan)

Discovered via single-drug scan of semaglutide. PRR = 4.33 (95% CI 4.21–4.45), n = 4287 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 03e1101968b13d4d…

Semaglutide → Vomiting — Audit-grade candidate (scan)

Discovered via single-drug scan of semaglutide. PRR = 4.23 (95% CI 4.08–4.40), n = 2516 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: ff1b0925e594a184…

Semaglutide → Abdominal pain upper — Audit-grade candidate (scan)

Discovered via single-drug scan of semaglutide. PRR = 3.71 (95% CI 3.49–3.95), n = 956 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 22fefb73bbf42920…

Semaglutide → Inappropriate schedule of product administration — Audit-grade candidate (scan)

Discovered via single-drug scan of semaglutide. PRR = 3.34 (95% CI 3.11–3.59), n = 729 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: a29de24c19020d4c…

Semaglutide → Abdominal discomfort — Audit-grade candidate (scan)

Discovered via single-drug scan of semaglutide. PRR = 3.14 (95% CI 2.91–3.38), n = 658 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 6759dfda43e17e62…

Semaglutide → Diarrhoea — Audit-grade candidate (scan)

Discovered via single-drug scan of semaglutide. PRR = 2.83 (95% CI 2.72–2.94), n = 2315 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: e4685ee2e0247dc6…

Semaglutide → COVID-19 — Audit-grade candidate (scan)

Discovered via single-drug scan of semaglutide. PRR = 2.74 (95% CI 2.54–2.95), n = 670 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 6c92216b4070d988…

Canagliflozin → Diabetic foot infection — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 938.95, n = 770 cases.
Candidate (class scan)
sha1: b78aeec9568cafda…

Canagliflozin → Toe amputation — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 556.49, n = 2092 cases.
Candidate (class scan)
sha1: 1f487e80ab5aee7a…

Empagliflozin → Euglycaemic diabetic ketoacidosis — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 207.83, n = 807 cases.
Candidate (class scan)
sha1: 70bd2500ee4824ca…

Canagliflozin → Leg amputation — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 169.87, n = 731 cases.
Candidate (class scan)
sha1: b51e7a901005c3bb…

Canagliflozin → Diabetic foot — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 164.03, n = 749 cases.
Candidate (class scan)
sha1: 09949374f20be5a6…

Canagliflozin → Diabetic ketoacidosis — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 104.61, n = 3242 cases.
Candidate (class scan)
sha1: 43d6db7a0c737ba5…

Canagliflozin → Osteomyelitis — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 91.61, n = 2069 cases.
Candidate (class scan)
sha1: fa02c143023fbdfb…

Canagliflozin → Gangrene — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 89.62, n = 1022 cases.
Candidate (class scan)
sha1: 200ebc899505e144…

Empagliflozin → Diabetic ketoacidosis — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 85.43, n = 2707 cases.
Candidate (class scan)
sha1: cf5f46a3d0576822…

Ertugliflozin → Inability to afford medication — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 42.64, n = 25 cases.
Candidate (class scan)
sha1: 4201f45058145a8a…

Dapagliflozin → Diabetic ketoacidosis — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 40.64, n = 1359 cases.
Candidate (class scan)
sha1: a3d1f4699fd1678b…

Ertugliflozin → Diabetic ketoacidosis — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 34.94, n = 59 cases.
Candidate (class scan)
sha1: cc77930ac5378ad5…

Canagliflozin → Fungal infection — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 31.49, n = 1423 cases.
Candidate (class scan)
sha1: 620f50db169e8489…

Ertugliflozin → Fungal infection — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 27.92, n = 63 cases.
Candidate (class scan)
sha1: 05a1e4f96953d382…

Ertugliflozin → Diabetes mellitus inadequate control — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 26.14, n = 28 cases.
Candidate (class scan)
sha1: bf770978b76f8544…

Empagliflozin → Fungal infection — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 25.82, n = 1175 cases.
Candidate (class scan)
sha1: 6df499ef30c8c0ab…

Dapagliflozin → Fungal infection — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 24.77, n = 1129 cases.
Candidate (class scan)
sha1: 7a65d7e1b4fdb202…

Empagliflozin → Ketoacidosis — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 23.71, n = 1029 cases.
Candidate (class scan)
sha1: b8194fbf636a222d…

Sotagliflozin → Therapy interrupted — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 19.71, n = 33 cases.
Candidate (class scan)
sha1: fe09ed8e3e747336…

Sotagliflozin → Fungal infection — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 18.13, n = 17 cases.
Candidate (class scan)
sha1: 5c5a61a6827cb793…

Canagliflozin → Cellulitis — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 13.95, n = 983 cases.
Candidate (class scan)
sha1: 810952d762d0ed90…

Empagliflozin → Pollakiuria — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 13.85, n = 715 cases.
Candidate (class scan)
sha1: 2f742f3c5fc10b73…

Canagliflozin → Acute kidney injury — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 9.83, n = 1862 cases.
Candidate (class scan)
sha1: 392e31020e81b2c6…

Dapagliflozin → Blood glucose increased — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 6.48, n = 1543 cases.
Candidate (class scan)
sha1: 40f3290a48c9bfcf…

Ertugliflozin → Urinary tract infection — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 6.46, n = 70 cases.
Candidate (class scan)
sha1: 468a0a0063212619…

Ertugliflozin → No adverse event — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 6.44, n = 69 cases.
Candidate (class scan)
sha1: a8e3e20d2f45cff8…

Empagliflozin → Blood glucose increased — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 6.20, n = 1475 cases.
Candidate (class scan)
sha1: 9a07cb26fd62a12a…

Ertugliflozin → Product dose omission issue — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 5.33, n = 89 cases.
Candidate (class scan)
sha1: 8a382f8f90a69e53…

Ertugliflozin → Blood glucose increased — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 5.21, n = 60 cases.
Candidate (class scan)
sha1: 4c2a199d81e5258d…

Sotagliflozin → Urinary tract infection — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 5.11, n = 23 cases.
Candidate (class scan)
sha1: 87b55d9d699536b9…

Dapagliflozin → Dehydration — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 5.05, n = 847 cases.
Candidate (class scan)
sha1: b6de532c94672e24…

Canagliflozin → Blood glucose increased — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 4.59, n = 1095 cases.
Candidate (class scan)
sha1: c735f396d077177b…

Canagliflozin → Urinary tract infection — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 4.13, n = 927 cases.
Candidate (class scan)
sha1: 2afbf2faffc15ad6…

Dapagliflozin → Acute kidney injury — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 4.12, n = 786 cases.
Candidate (class scan)
sha1: 8b524b2f4a1f226e…

Sotagliflozin → Dizziness — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 4.08, n = 52 cases.
Candidate (class scan)
sha1: 9ae2c6e40aa51a6e…

Canagliflozin → Dehydration — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 3.85, n = 646 cases.
Candidate (class scan)
sha1: bdaa025a47fc3bab…

Empagliflozin → Dehydration — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 3.82, n = 642 cases.
Candidate (class scan)
sha1: a18e8b3330c648aa…

Empagliflozin → Weight decreased — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 3.80, n = 1334 cases.
Candidate (class scan)
sha1: 27de7a3f42dba7a0…

Dapagliflozin → Weight decreased — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 3.80, n = 1333 cases.
Candidate (class scan)
sha1: 8c7aa8d6b4081c0d…

Canagliflozin → Weight decreased — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 3.47, n = 1219 cases.
Candidate (class scan)
sha1: 1e8d4038d73985d1…

Sotagliflozin → Hospitalisation — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 3.41, n = 13 cases.
Candidate (class scan)
sha1: c94296330e1ef7d4…

Dapagliflozin → Urinary tract infection — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 3.41, n = 767 cases.
Candidate (class scan)
sha1: 7c7b5c3e04e827ea…

Sotagliflozin → Product use issue — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 3.39, n = 23 cases.
Candidate (class scan)
sha1: 4780631cea9c557e…

Empagliflozin → Urinary tract infection — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 3.33, n = 748 cases.
Candidate (class scan)
sha1: a1731fdcf12c64b4…

Empagliflozin → Acute kidney injury — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 3.05, n = 583 cases.
Candidate (class scan)
sha1: a957247a913cd497…

Sotagliflozin → Diarrhoea — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 2.87, n = 47 cases.
Candidate (class scan)
sha1: d1f74fe219a87740…

Ertugliflozin → Vomiting — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 2.82, n = 81 cases.
Candidate (class scan)
sha1: 1c409280ba5ea551…

Canagliflozin → Renal failure — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 2.81, n = 653 cases.
Candidate (class scan)
sha1: 523c6429bb103232…

Sotagliflozin → Abdominal discomfort — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 2.62, n = 11 cases.
Candidate (class scan)
sha1: eb520e9cd33f32e7…

Ertugliflozin → Decreased appetite — Audit-grade candidate (class scan)

Discovered via class scan of SGLT2 inhibitors. PRR = 2.14, n = 30 cases.
Candidate (class scan)
sha1: 311d95a991bd1ac6…

Clozapine → Granulocytopenia — Audit-grade candidate (scan)

Discovered via single-drug scan of clozapine. PRR = 145.27 (95% CI 135.41–155.84), n = 898 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: e1a8095dc39bfce1…

Clozapine → Neutrophil count increased — Audit-grade candidate (scan)

Discovered via single-drug scan of clozapine. PRR = 123.01 (95% CI 116.44–129.95), n = 1410 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 68450706f61c4dbd…

Clozapine → Schizophrenia — Audit-grade candidate (scan)

Discovered via single-drug scan of clozapine. PRR = 71.91 (95% CI 67.59–76.52), n = 1052 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 7e2cf27e44a01b28…

Clozapine → White blood cell count increased — Audit-grade candidate (scan)

Discovered via single-drug scan of clozapine. PRR = 35.18 (95% CI 33.54–36.90), n = 1653 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 7b6c3a97c7991793…

Clozapine → Agranulocytosis — Audit-grade candidate (scan)

Discovered via single-drug scan of clozapine. PRR = 26.69 (95% CI 24.62–28.93), n = 599 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 040b585e95e16426…

Clozapine → Hospitalisation — Audit-grade candidate (scan)

Discovered via single-drug scan of clozapine. PRR = 19.55 (95% CI 18.96–20.15), n = 3641 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 61623c1f24590208…

Clozapine → Mental impairment — Audit-grade candidate (scan)

Discovered via single-drug scan of clozapine. PRR = 18.91 (95% CI 17.42–20.53), n = 569 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: ab0b23ceb2563aa5…

Clozapine → Psychotic disorder — Audit-grade candidate (scan)

Discovered via single-drug scan of clozapine. PRR = 18.79 (95% CI 17.49–20.18), n = 748 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: b7f29a0a76c4cec3…

Clozapine → Neutrophil count decreased — Audit-grade candidate (scan)

Discovered via single-drug scan of clozapine. PRR = 13.37 (95% CI 12.40–14.42), n = 671 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: e6236805a12b2521…

Clozapine → Treatment noncompliance — Audit-grade candidate (scan)

Discovered via single-drug scan of clozapine. PRR = 8.58 (95% CI 7.91–9.30), n = 580 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 870ad0c2e1a07fa4…

Clozapine → Neutropenia — Audit-grade candidate (scan)

Discovered via single-drug scan of clozapine. PRR = 7.40 (95% CI 7.07–7.73), n = 1811 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 2fc65b63e2705176…

Clozapine → White blood cell count decreased — Audit-grade candidate (scan)

Discovered via single-drug scan of clozapine. PRR = 7.01 (95% CI 6.58–7.46), n = 954 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: b9525e3f8c293078…

Clozapine → Haemoglobin decreased — Audit-grade candidate (scan)

Discovered via single-drug scan of clozapine. PRR = 5.21 (95% CI 4.84–5.61), n = 691 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: f74c0a3edbd30193…

Clozapine → Constipation — Audit-grade candidate (scan)

Discovered via single-drug scan of clozapine. PRR = 2.02 (95% CI 1.86–2.19), n = 546 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 1c944e46b1bd508e…

Hydroxychloroquine → Drug hypersensitivity — Audit-grade candidate (scan)

Discovered via single-drug scan of hydroxychloroquine. PRR = 5.86 (95% CI 5.57–6.17), n = 1437 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: f8a907233eadad92…

Hydroxychloroquine → Arthralgia — Audit-grade candidate (scan)

Discovered via single-drug scan of hydroxychloroquine. PRR = 4.75 (95% CI 4.57–4.93), n = 2461 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 1b2750fc405ece13…

Hydroxychloroquine → Condition aggravated — Audit-grade candidate (scan)

Discovered via single-drug scan of hydroxychloroquine. PRR = 4.13 (95% CI 3.94–4.34), n = 1561 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 9841222b43a18510…

Hydroxychloroquine → Drug ineffective — Audit-grade candidate (scan)

Discovered via single-drug scan of hydroxychloroquine. PRR = 3.92 (95% CI 3.84–4.01), n = 6766 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: d3579dc594594b75…

Hydroxychloroquine → Pain in extremity — Audit-grade candidate (scan)

Discovered via single-drug scan of hydroxychloroquine. PRR = 3.63 (95% CI 3.45–3.83), n = 1353 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 5fd4b52e7474ccae…

Hydroxychloroquine → Fatigue — Audit-grade candidate (scan)

Discovered via single-drug scan of hydroxychloroquine. PRR = 2.23 (95% CI 2.14–2.32), n = 2196 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: a5d5913cdc07eb8c…

Hydroxychloroquine → Malaise — Audit-grade candidate (scan)

Discovered via single-drug scan of hydroxychloroquine. PRR = 2.22 (95% CI 2.10–2.35), n = 1235 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 5c425e86fbc6c99b…

Hydroxychloroquine → Nausea — Audit-grade candidate (scan)

Discovered via single-drug scan of hydroxychloroquine. PRR = 2.12 (95% CI 2.03–2.21), n = 2103 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 69d72b555bad60c9…

Hydroxychloroquine → Headache — Audit-grade candidate (scan)

Discovered via single-drug scan of hydroxychloroquine. PRR = 2.07 (95% CI 1.98–2.17), n = 1664 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 1aff618f9ad1fac3…

Varenicline → Abnormal dreams — Audit-grade candidate (scan)

Discovered via single-drug scan of varenicline. PRR = 56.87 (95% CI 54.36–59.51), n = 1876 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 3fae907ac1e7ec2e…

Varenicline → Sneezing — Audit-grade candidate (scan)

Discovered via single-drug scan of varenicline. PRR = 27.61 (95% CI 25.70–29.67), n = 752 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: f34358cd639987ed…

Varenicline → Nightmare — Audit-grade candidate (scan)

Discovered via single-drug scan of varenicline. PRR = 24.24 (95% CI 22.81–25.75), n = 1037 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 7ea82f1cdaf6bd36…

Varenicline → Suicidal ideation — Audit-grade candidate (scan)

Discovered via single-drug scan of varenicline. PRR = 5.37 (95% CI 4.96–5.80), n = 619 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 32f5721549fc7a1a…

Varenicline → Depression — Audit-grade candidate (scan)

Discovered via single-drug scan of varenicline. PRR = 3.53 (95% CI 3.34–3.74), n = 1139 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: d349607759b05757…

Varenicline → Feeling abnormal — Audit-grade candidate (scan)

Discovered via single-drug scan of varenicline. PRR = 3.41 (95% CI 3.22–3.62), n = 1038 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 97e671826e7695b0…

Varenicline → Drug hypersensitivity — Audit-grade candidate (scan)

Discovered via single-drug scan of varenicline. PRR = 3.20 (95% CI 2.99–3.43), n = 787 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: d2c92b28415ea4d5…

Varenicline → Nausea — Audit-grade candidate (scan)

Discovered via single-drug scan of varenicline. PRR = 2.92 (95% CI 2.82–3.02), n = 2892 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: f6bb8fb74939496e…

Varenicline → Anxiety — Audit-grade candidate (scan)

Discovered via single-drug scan of varenicline. PRR = 2.80 (95% CI 2.63–2.97), n = 1030 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: c90e100f9a16af94…

Varenicline → Insomnia — Audit-grade candidate (scan)

Discovered via single-drug scan of varenicline. PRR = 2.74 (95% CI 2.58–2.91), n = 1030 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: 1c96dc09c2beb650…

Varenicline → Malaise — Audit-grade candidate (scan)

Discovered via single-drug scan of varenicline. PRR = 2.12 (95% CI 2.00–2.24), n = 1177 cases. Pre-reg locked at submission time.
Candidate (scan)
sha1: a1d0884c9f3aad49…

Rosiglitazone → myocardial infarction — Null result

Caliper validation of the submitted claim (drug=rosiglitazone, AE=myocardial infarction, comparator=pioglitazone). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: 2c0322078e007a2a…

Isotretinoin → depression — Audit-grade candidate

Caliper validation of the submitted claim (drug=isotretinoin, AE=depression). PRR = 6.04 (95% CI 5.79–6.31), n = 1943 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 1a586f4e8c7a1af1…

Valproate → neural tube defects — Null result

Caliper validation of the submitted claim (drug=valproate, AE=neural tube defects). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: 878711c9921f8dc1…

Atorvastatin → new-onset diabetes — Null result

Caliper validation of the submitted claim (drug=atorvastatin, AE=new-onset diabetes, comparator=placebo). BELOW_DEDUP_THRESHOLD — only 0 unique cases after dedup; insufficient signal density
Did not validate
sha1: 0c54c7915df8c8c6…

Valproate → Neural tube defect — Audit-grade candidate

Caliper validation of the submitted claim (drug=valproate, AE=Neural tube defect). PRR = 12.74 (95% CI 6.60–24.59), n = 9 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: 1e8ca65cd73b0d9c…

Rosiglitazone → Myocardial infarction — Null result

Caliper validation of the submitted claim (drug=rosiglitazone, AE=Myocardial infarction, comparator=pioglitazone). NO_DRUG_DATA_FOUND — 'rosiglitazone' returned zero FAERS reports at the drug-name lookup stage, before any reaction-term filtering ran. This is a probable drug-name/spelling/lookup issue, NOT evidence of safety — verify the drug name matches FAERS's medicinalproduct convention (try the brand name or an RxCUI) before treating this as a null result.
Did not validate
sha1: 944e908c07405c25…

Valproic Acid → Neural tube defect — Null result

Caliper validation of the submitted claim (drug=valproic acid, AE=Neural tube defect). BELOW_DEDUP_THRESHOLD — 7 raw reports matched the reaction term, but only 4 unique cases remained after dedup; genuine signal-density limitation (the term was found, there just isn't enough independent evidence yet).
Did not validate
sha1: 01c683ff790d2314…

Avandia → Myocardial infarction — Null result

Caliper validation of the submitted claim (drug=Avandia, AE=Myocardial infarction, comparator=Actos). NO_DRUG_DATA_FOUND — 'Avandia' returned zero FAERS reports at the drug-name lookup stage, before any reaction-term filtering ran. This is a probable drug-name/spelling/lookup issue, NOT evidence of safety — verify the drug name matches FAERS's medicinalproduct convention (try the brand name or an RxCUI) before treating this as a null result.
Did not validate
sha1: 9f241b36fafdb7b8…

Rosiglitazone → Myocardial infarction — Audit-grade candidate

Caliper validation of the submitted claim (drug=rosiglitazone, AE=Myocardial infarction, comparator=pioglitazone). PRR = 20.93 (95% CI 19.72–22.21), n = 863 cases. Pre-reg locked at submission; awaiting Adam's review before public ship.
Candidate (awaiting expert review)
sha1: c65c10e1e85c090e…