Clozapine → Schizophrenia — Audit-grade candidate (scan)

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Ledger entry · candidate

Clozapine → Schizophrenia — Audit-grade candidate (scan)

Drug: clozapine · AE: Schizophrenia

Discovered via single-drug scan of clozapine. PRR = 71.91 (95% CI 67.59–76.52), n = 1052 cases. Pre-reg locked at submission time.

Disproportionality

PRR: 71.91482196394101 (95% CI 67.59–76.52)
Yates χ²: 67244.4072698432
Cases (case-drug + AE): n = 1052
Verdict: PASSES_ALL_GATES — PRR=71.91 (95% CI 67.59–76.52), n=1052 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

MedDRA PT	n
No reactions surfaced in cohort.

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

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Reference: 7e2cf27e44a01b28ebdeb4d5a05556fac506ba68