Canagliflozin → Acute kidney injury — Audit-grade candidate (class scan)

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Ledger entry · candidate

Canagliflozin → Acute kidney injury — Audit-grade candidate (class scan)

Drug: canagliflozin · AE: Acute kidney injury

Discovered via class scan of SGLT2 inhibitors. PRR = 9.83, n = 1862 cases.

Disproportionality

PRR: 9.830093338288256
Yates χ²: n/a
Cases (case-drug + AE): n = 1862
Verdict: PASSES_ALL_GATES — PRR=9.83 (95% CI 9.41–10.27), n=1862 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

MedDRA PT	n
No reactions surfaced in cohort.

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

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Reference: 392e31020e81b2c6bdfd1ba71d1a7a03f9e33996