Varenicline → Sneezing — Audit-grade candidate (scan)

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Ledger entry · candidate

Varenicline → Sneezing — Audit-grade candidate (scan)

Drug: varenicline · AE: Sneezing

Discovered via single-drug scan of varenicline. PRR = 27.61 (95% CI 25.70–29.67), n = 752 cases. Pre-reg locked at submission time.

Disproportionality

PRR: 27.6138587286238 (95% CI 25.70–29.67)
Yates χ²: 18614.03459439478
Cases (case-drug + AE): n = 752
Verdict: PASSES_ALL_GATES — PRR=27.61 (95% CI 25.70–29.67), n=752 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

MedDRA PT	n
No reactions surfaced in cohort.

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

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Reference: f34358cd639987ed02f65eb801d6ed3cb4a0b10a