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Ledger entry · null-result

Valproic Acid → Neural tube defect — Null result

Drug: valproic acid · AE: Neural tube defect

Caliper validation of the submitted claim (drug=valproic acid, AE=Neural tube defect). BELOW_DEDUP_THRESHOLD — 7 raw reports matched the reaction term, but only 4 unique cases remained after dedup; genuine signal-density limitation (the term was found, there just isn't enough independent evidence yet).

Disproportionality

Top reactions in cohort

MedDRA PTn
DRUG INTERACTION4
NEURAL TUBE DEFECT4
Foetal exposure during pregnancy3
Neural tube defect3
Arnold-Chiari malformation1
Cerebral ventricle dilatation1
Spina bifida1

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

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Reference: 01c683ff790d2314a91cb0b1163aae3272321122