Clozapine → Agranulocytosis — Audit-grade candidate (scan)

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Ledger entry · candidate

Clozapine → Agranulocytosis — Audit-grade candidate (scan)

Drug: clozapine · AE: Agranulocytosis

Discovered via single-drug scan of clozapine. PRR = 26.69 (95% CI 24.62–28.93), n = 599 cases. Pre-reg locked at submission time.

Disproportionality

PRR: 26.687364772326788 (95% CI 24.62–28.93)
Yates χ²: 14300.8736873132
Cases (case-drug + AE): n = 599
Verdict: PASSES_ALL_GATES — PRR=26.69 (95% CI 24.62–28.93), n=599 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

MedDRA PT	n
No reactions surfaced in cohort.

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

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Reference: 040b585e95e164265ea998e572f4a87d6aaac833