Semaglutide → Weight decreased — Audit-grade candidate (scan)

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Ledger entry · candidate

Semaglutide → Weight decreased — Audit-grade candidate (scan)

Drug: semaglutide · AE: Weight decreased

Discovered via single-drug scan of semaglutide. PRR = 4.70 (95% CI 4.49–4.93), n = 1648 cases. Pre-reg locked at submission time.

Disproportionality

PRR: 4.700490852527476 (95% CI 4.49–4.93)
Yates χ²: 4833.625206565303
Cases (case-drug + AE): n = 1648
Verdict: PASSES_ALL_GATES — PRR=4.70 (95% CI 4.49–4.93), n=1648 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

MedDRA PT	n
No reactions surfaced in cohort.

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

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Reference: 93b77ef0ed63b1f9fec719e1003158dc7e2eddf1