Canagliflozin → Dehydration — Audit-grade candidate (class scan)

← All findings ⬇ Download signed audit packet

Ledger entry · candidate

Canagliflozin → Dehydration — Audit-grade candidate (class scan)

Drug: canagliflozin · AE: Dehydration

Discovered via class scan of SGLT2 inhibitors. PRR = 3.85, n = 646 cases.

Disproportionality

PRR: 3.8474073720681985
Yates χ²: n/a
Cases (case-drug + AE): n = 646
Verdict: PASSES_ALL_GATES — PRR=3.85 (95% CI 3.56–4.15), n=646 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

MedDRA PT	n
No reactions surfaced in cohort.

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

Independent Verification & Validation

Every finding includes an in-engine adversary review at no cost. For findings you plan to cite in a regulatory submission, scientific publication, or board-grade decision, we offer an additional layer of independent, audit-grade verification — reviewed by an externally-trained system that has never seen your data, your training corpus, or our hardware, and cryptographically signed.

Reference: bdaa025a47fc3bab82634e9ca15a9eb024ef2f72