Clozapine → Neutropenia — Audit-grade candidate (scan)

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Ledger entry · candidate

Clozapine → Neutropenia — Audit-grade candidate (scan)

Drug: clozapine · AE: Neutropenia

Discovered via single-drug scan of clozapine. PRR = 7.40 (95% CI 7.07–7.73), n = 1811 cases. Pre-reg locked at submission time.

Disproportionality

PRR: 7.3962591070733374 (95% CI 7.07–7.73)
Yates χ²: 10010.66994911422
Cases (case-drug + AE): n = 1811
Verdict: PASSES_ALL_GATES — PRR=7.40 (95% CI 7.07–7.73), n=1811 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

MedDRA PT	n
No reactions surfaced in cohort.

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

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Reference: 2fc65b63e27051760773cdc08d646c4a4d1797fc