Hydroxychloroquine → Pain in extremity — Audit-grade candidate (scan)

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Ledger entry · candidate

Hydroxychloroquine → Pain in extremity — Audit-grade candidate (scan)

Drug: hydroxychloroquine · AE: Pain in extremity

Discovered via single-drug scan of hydroxychloroquine. PRR = 3.63 (95% CI 3.45–3.83), n = 1353 cases. Pre-reg locked at submission time.

Disproportionality

PRR: 3.631237203247698 (95% CI 3.45–3.83)
Yates χ²: 2602.327495642469
Cases (case-drug + AE): n = 1353
Verdict: PASSES_ALL_GATES — PRR=3.63 (95% CI 3.45–3.83), n=1353 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

MedDRA PT	n
No reactions surfaced in cohort.

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

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Reference: 5fd4b52e7474ccae2770b2413b9eb93c8e5ced49