Aspirin → headache — Null result

← All findings ⬇ Download signed audit packet

Ledger entry · null-result

Aspirin → headache — Null result

Drug: aspirin · AE: headache

Caliper validation of the submitted claim (drug=aspirin, AE=headache). BELOW_PRR_THRESHOLD — disproportionality not significant (PRR=0.86, lower CI=0.80)

Disproportionality

PRR: 0.8633132315453584 (95% CI 0.80–0.93)
Yates χ²: 15.363064049534309
Cases (case-drug + AE): n = 695
Verdict: BELOW_PRR_THRESHOLD — disproportionality not significant (PRR=0.86, lower CI=0.80)

Top reactions in cohort

MedDRA PT	n
Headache	50
Nausea	15
Dizziness	13
Dyspnoea	11
Drug ineffective	10
Pain	9
Feeling abnormal	8
Fall	7

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

Independent Verification & Validation

Every finding includes an in-engine adversary review at no cost. For findings you plan to cite in a regulatory submission, scientific publication, or board-grade decision, we offer an additional layer of independent, audit-grade verification — reviewed by an externally-trained system that has never seen your data, your training corpus, or our hardware, and cryptographically signed.

Reference: 38b0633b1406e350c1205960e3321d05f7115fee