Canagliflozin → Weight decreased — Audit-grade candidate (class scan)

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Ledger entry · candidate

Canagliflozin → Weight decreased — Audit-grade candidate (class scan)

Drug: canagliflozin · AE: Weight decreased

Discovered via class scan of SGLT2 inhibitors. PRR = 3.47, n = 1219 cases.

Disproportionality

PRR: 3.4713510212042307
Yates χ²: n/a
Cases (case-drug + AE): n = 1219
Verdict: PASSES_ALL_GATES — PRR=3.47 (95% CI 3.29–3.67), n=1219 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

MedDRA PT	n
No reactions surfaced in cohort.

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

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Reference: 1e8d4038d73985d178fc0ec8cddb40e36f0cea88