Clozapine → Neutrophil count increased — Audit-grade candidate (scan)

← All findings ⬇ Download signed audit packet

Ledger entry · candidate

Clozapine → Neutrophil count increased — Audit-grade candidate (scan)

Drug: clozapine · AE: Neutrophil count increased

Discovered via single-drug scan of clozapine. PRR = 123.01 (95% CI 116.44–129.95), n = 1410 cases. Pre-reg locked at submission time.

Disproportionality

PRR: 123.00765212529919 (95% CI 116.44–129.95)
Yates χ²: 147051.62214138845
Cases (case-drug + AE): n = 1410
Verdict: PASSES_ALL_GATES — PRR=123.01 (95% CI 116.44–129.95), n=1410 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

MedDRA PT	n
No reactions surfaced in cohort.

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

Independent Verification & Validation

Every finding includes an in-engine adversary review at no cost. For findings you plan to cite in a regulatory submission, scientific publication, or board-grade decision, we offer an additional layer of independent, audit-grade verification — reviewed by an externally-trained system that has never seen your data, your training corpus, or our hardware, and cryptographically signed.

Reference: 68450706f61c4dbd03d33b184ef6dbbf8b4da446