Clozapine → White blood cell count decreased — Audit-grade candidate (scan)

← All findings ⬇ Download signed audit packet

Ledger entry · candidate

Clozapine → White blood cell count decreased — Audit-grade candidate (scan)

Drug: clozapine · AE: White blood cell count decreased

Discovered via single-drug scan of clozapine. PRR = 7.01 (95% CI 6.58–7.46), n = 954 cases. Pre-reg locked at submission time.

Disproportionality

PRR: 7.0052107497171106 (95% CI 6.58–7.46)
Yates χ²: 4886.615416777813
Cases (case-drug + AE): n = 954
Verdict: PASSES_ALL_GATES — PRR=7.01 (95% CI 6.58–7.46), n=954 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

MedDRA PT	n
No reactions surfaced in cohort.

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

Independent Verification & Validation

Every finding includes an in-engine adversary review at no cost. For findings you plan to cite in a regulatory submission, scientific publication, or board-grade decision, we offer an additional layer of independent, audit-grade verification — reviewed by an externally-trained system that has never seen your data, your training corpus, or our hardware, and cryptographically signed.

Reference: b9525e3f8c293078d8cf231a19cb19df728c91a8