Semaglutide → Constipation — Audit-grade candidate (scan)

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Ledger entry · candidate

Semaglutide → Constipation — Audit-grade candidate (scan)

Drug: semaglutide · AE: Constipation

Discovered via single-drug scan of semaglutide. PRR = 4.56 (95% CI 4.32–4.82), n = 1231 cases. Pre-reg locked at submission time.

Disproportionality

PRR: 4.562433432024029 (95% CI 4.32–4.82)
Yates χ²: 3436.231203136203
Cases (case-drug + AE): n = 1231
Verdict: PASSES_ALL_GATES — PRR=4.56 (95% CI 4.32–4.82), n=1231 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

MedDRA PT	n
No reactions surfaced in cohort.

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

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Reference: 1e025a00ff49f109fdec00c2de117a4ddd9eb48a