Canagliflozin → Osteomyelitis — Audit-grade candidate (class scan)

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Ledger entry · candidate

Canagliflozin → Osteomyelitis — Audit-grade candidate (class scan)

Drug: canagliflozin · AE: Osteomyelitis

Discovered via class scan of SGLT2 inhibitors. PRR = 91.61, n = 2069 cases.

Disproportionality

PRR: 91.60679278073088
Yates χ²: n/a
Cases (case-drug + AE): n = 2069
Verdict: PASSES_ALL_GATES — PRR=91.61 (95% CI 87.67–95.72), n=2069 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

MedDRA PT	n
No reactions surfaced in cohort.

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

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Reference: fa02c143023fbdfb52f22cb177207ffd842ec631