Clozapine → Neutrophil count decreased — Audit-grade candidate (scan)

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Ledger entry · candidate

Clozapine → Neutrophil count decreased — Audit-grade candidate (scan)

Drug: clozapine · AE: Neutrophil count decreased

Discovered via single-drug scan of clozapine. PRR = 13.37 (95% CI 12.40–14.42), n = 671 cases. Pre-reg locked at submission time.

Disproportionality

PRR: 13.373186482484465 (95% CI 12.40–14.42)
Yates χ²: 7552.789315940975
Cases (case-drug + AE): n = 671
Verdict: PASSES_ALL_GATES — PRR=13.37 (95% CI 12.40–14.42), n=671 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

MedDRA PT	n
No reactions surfaced in cohort.

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.

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Reference: e6236805a12b2521b516dde32547961b230f45f0