Ledger entry · candidate
Canagliflozin → Osteomyelitis — Audit-grade candidate (class scan)
Drug: canagliflozin · AE: Osteomyelitis
Discovered via class scan of SGLT2 inhibitors. PRR = 91.61, n = 2069 cases.
Disproportionality
- PRR: 91.60679278073088
- Yates χ2: n/a
- Cases (case-drug + AE): n = 2069
- Verdict:
PASSES_ALL_GATES — PRR=91.61 (95% CI 87.67–95.72), n=2069 cases; flagged for clinical expert review, NOT for external escalation without manual verification
Top reactions in cohort
| MedDRA PT | n |
|---|
| No reactions surfaced in cohort. |
Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.