Ledger entry · candidate
Clozapine → Neutrophil count decreased — Audit-grade candidate (scan)
Drug: clozapine · AE: Neutrophil count decreased
Discovered via single-drug scan of clozapine. PRR = 13.37 (95% CI 12.40–14.42), n = 671 cases. Pre-reg locked at submission time.
Disproportionality
- PRR: 13.373186482484465
(95% CI 12.40–14.42)
- Yates χ2: 7552.789315940975
- Cases (case-drug + AE): n = 671
- Verdict:
PASSES_ALL_GATES — PRR=13.37 (95% CI 12.40–14.42), n=671 cases; flagged for clinical expert review, NOT for external escalation without manual verification
Top reactions in cohort
| MedDRA PT | n |
|---|
| No reactions surfaced in cohort. |
Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.