Clozapine → Granulocytopenia — Audit-grade candidate (scan)

Drug: clozapine · AE: Granulocytopenia

Discovered via single-drug scan of clozapine. PRR = 145.27 (95% CI 135.41–155.84), n = 898 cases. Pre-reg locked at submission time.

Disproportionality

• PRR: 145.26663103163418 (95% CI 135.41–155.84)
• Yates χ²: 108108.91959599071
• Cases (case-drug + AE): n = 898
• Verdict: PASSES_ALL_GATES — PRR=145.27 (95% CI 135.41–155.84), n=898 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.