Hydroxychloroquine → Condition aggravated — Audit-grade candidate (scan)

Drug: hydroxychloroquine · AE: Condition aggravated

Discovered via single-drug scan of hydroxychloroquine. PRR = 4.13 (95% CI 3.94–4.34), n = 1561 cases. Pre-reg locked at submission time.

Disproportionality

• PRR: 4.1335758728266505 (95% CI 3.94–4.34)
• Yates χ²: 3739.7246173407216
• Cases (case-drug + AE): n = 1561
• Verdict: PASSES_ALL_GATES — PRR=4.13 (95% CI 3.94–4.34), n=1561 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.