Clozapine → Neutrophil count increased — Audit-grade candidate (scan)

Drug: clozapine · AE: Neutrophil count increased

Discovered via single-drug scan of clozapine. PRR = 123.01 (95% CI 116.44–129.95), n = 1410 cases. Pre-reg locked at submission time.

Disproportionality

• PRR: 123.00765212529919 (95% CI 116.44–129.95)
• Yates χ²: 147051.62214138845
• Cases (case-drug + AE): n = 1410
• Verdict: PASSES_ALL_GATES — PRR=123.01 (95% CI 116.44–129.95), n=1410 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.