Ledger entry · candidate
Clozapine → Neutropenia — Audit-grade candidate (scan)
Drug: clozapine · AE: Neutropenia
Discovered via single-drug scan of clozapine. PRR = 7.40 (95% CI 7.07–7.73), n = 1811 cases. Pre-reg locked at submission time.
Disproportionality
- PRR: 7.3962591070733374
(95% CI 7.07–7.73)
- Yates χ2: 10010.66994911422
- Cases (case-drug + AE): n = 1811
- Verdict:
PASSES_ALL_GATES — PRR=7.40 (95% CI 7.07–7.73), n=1811 cases; flagged for clinical expert review, NOT for external escalation without manual verification
Top reactions in cohort
| MedDRA PT | n |
|---|
| No reactions surfaced in cohort. |
Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.