Ledger entry · candidate
Semaglutide → Constipation — Audit-grade candidate (scan)
Drug: semaglutide · AE: Constipation
Discovered via single-drug scan of semaglutide. PRR = 4.56 (95% CI 4.32–4.82), n = 1231 cases. Pre-reg locked at submission time.
Disproportionality
- PRR: 4.562433432024029
(95% CI 4.32–4.82)
- Yates χ2: 3436.231203136203
- Cases (case-drug + AE): n = 1231
- Verdict:
PASSES_ALL_GATES — PRR=4.56 (95% CI 4.32–4.82), n=1231 cases; flagged for clinical expert review, NOT for external escalation without manual verification
Top reactions in cohort
| MedDRA PT | n |
|---|
| No reactions surfaced in cohort. |
Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.