Hydroxychloroquine → Arthralgia — Audit-grade candidate (scan)

Drug: hydroxychloroquine · AE: Arthralgia

Discovered via single-drug scan of hydroxychloroquine. PRR = 4.75 (95% CI 4.57–4.93), n = 2461 cases. Pre-reg locked at submission time.

Disproportionality

• PRR: 4.745664836985359 (95% CI 4.57–4.93)
• Yates χ²: 7375.078639873593
• Cases (case-drug + AE): n = 2461
• Verdict: PASSES_ALL_GATES — PRR=4.75 (95% CI 4.57–4.93), n=2461 cases; flagged for clinical expert review, NOT for external escalation without manual verification

Top reactions in cohort

Source: openFDA FAERS, Caliper Engine v0. Pre-registration sha1 locked at submission time; ledger entry signed with platform Ed25519 key.